Early Cancer Biology (understanding the earliest steps of cancer development)

Dissecting the role of the senescent secretome in tumorigenesis

Principal Investigators: Dr Daniel Muñoz-Espín (Cambridge) & Dr Jim Korkola (OHSU)

Funded by: OHSU-CRUK PROJECT Award 2018

Deciphering the immune microenvironment in oesophageal adenocarcinoma and pre-cancerous lesions to a single cell resolution

Principal Investigators: Dr John Lizhe Zhuang (CRUK) & Dr Young Hwan Chang (OHSU)

Funded by: OHSU-CRUK SPARK Award 2018

Development of a microfluidic platform to study oncogene-induced single cell senescence

Principal Investigator: Dr Masashi Narita, CRUK Cambridge Institute
Co-Investigator: Professor Tuomas Knowles, Department of Physical Chemistry

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Understanding how mutant clones arise, expand and compete in our tissues using novel genetic lineage tracking tools and deep sequencing

Principal Investigator: Dr Jamie Blundell

Funded by: CRUK Cambridge Centre Early Detection Programme

Understanding the interface between cellular senescence, plasticity and the fundamental processes and mechanisms that lie at the origin of cancer

Principal Investigator: Dr Daniel Muñoz-Espín

Funded by: CRUK Cambridge Centre Early Detection Programme & MRC

Recurrent epigenetic changes and molecular pathway analysis

Principal Investigator: Dr Charlie Massie

Funded by: CRUK Cambridge Centre Early Detection Programme