Clinical translation (evaluating new diagnostics and interventions)

Developing early intervention strategies for high-risk clonal hematopoiesis

Principal Investigators: Prof George Vasilliou, University of Cambridge and Dr Ted Brown, Oregon Health and Science University.

Funded by: ACED Project Award 2022

Early Detection with Urine and Cognitive Assessment Multiplex (The EDUCAM study)

Principal Investigators: Mr Richard Mair and Rohit Sinha, University of Cambridge

Funded by: CRUK Early Detection Primer Award 2021

Towards an early detection programme for myeloid malignancies

Principal Investigator: Prof George Vassiliou, Professor of Haematological Medicine Wellcome-MRC Cambridge Stem Cell Institute

Funded by: Cancer Research UK Early Detection Project Award 2021

ELUSIVE: Early-stage LUng and Second primary cancer non-invasIVE detection by analysis of trace amounts of tumour DNA in liquid biopsy specimens

Principal Investigators: Dr Robert Rintoul, Royal Papworth Hospital & Dr Nitzan Rosenfeld, CRUK Cambridge Institute

Funded by: Cancer Research UK Early Detection Programme Award

Stratifying risk for early detection in hereditary breast and ovarian cancer

Principal Investigators: Dr Marc Tischkowitz, University of Cambridge; Dr Allison Kurian, Stanford University and Prof Gareth Evans, University of Manchester

Funded by: ACED Project Award 2020

Risk adaptive breast cancer screening: a tailored imaging approach

Principal Investigator: Professor Fiona Gilbert, School of Clinical Medicine and Addenbrooke’s Hospital, Cambridge
Joint Lead Applicant: Professor Paul Pharoah, Department of Public Health and Primary Care

Funded by: Cancer Research UK Early Detection Programme Award

Earlier Diagnosis in women at high risk of breast and ovarian cancer

Principal Investigator: Professor Doug Easton, Centre for Cancer Genetic Epidemiology,
Joint Lead Applicant: Dr Nitzan Rosenfeld, CRUK Cambridge Institute

Funded by: Cancer Research UK Early Detection Programme Award

Early detection of clinically-relevant mutational signatures

Principal Investigator: Dr Serena Nik-Zainal, MRC Cancer Unit

Funded by: Cancer Research UK Early Detection Project Award

PAN Cancer trial

Chief Investigator: Professor Rebecca Fitzgerald, MRC Cancer Unit
Principal Investigators:
Dr Massimiliano di Pietro, gastric and oesophageal cancers
Miss Victoria Snowdon, liver cancer

Funded by: Owlstone Medical Ltd (sponsors) and CRUK Cambridge Centre

Evaluation of photoacoustic imaging data to delineate benign and malignant disease in breast cancer

Principal Investigator: Professor Fiona Gilbert, Department of Radiology
Co- Investigator: Dr Sarah Bohndiek, Department of Physics

Funded by: Cancer Research UK Cancer Imaging Centre in Cambridge and Manchester

The PRIM multi-centre study to refine and target early detection in prostate cancer using imaging and biomarkers

Principal Investigator: Professor Vincent Gnanapragasam, Department of Surgery

Funded by: Addenbrooke's Charitable Trust & CRUK Cambridge Centre Urological Malignancies Programme

Feasibility of multi-spectral endoscopic imaging for detection of early neoplasia in Barrett's Oesophagus

Principal Investigator: Dr Sarah Bohndiek, Department of Physics
Co-Investigator: Professor Rebecca Fitzgerald, MRC Cancer Unit & Dale Waterhouse, Department of Engineering

Funded by: Cancer Research UK and Stand Up to Cancer

Combination of confocal laser endomicroscopy and a molecular biomarker panel for the early diagnosis of neoplasia in Barrett's oesophagus

Principal Investigator: Dr Massimiliano di Pietro, MRC Cancer Unit
Co-Investigator: Professor Lorenz Wernisch, MRC Biostatistics Unit

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Developing a national framework to identify and monitor individuals with inherited cancer syndromes

Principal Investigator: Dr Marc Tischkowitz, Department of Medical Genetics
Co-Investigator: Professor Paul Pharoah, Department of Public Health and Primary Care

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Second primary tumour early detection (SPoTtED)

Principal Investigator: Dr Robert Rintoul, Papworth Hospital
Co-Investigator: Dr Yoryos Lyratzopoulos, Department of Public Health and Primary Care

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2016