Clinical translation (evaluating new diagnostics and interventions)

ELUSIVE: Early-stage LUng and Second primary cancer non-invasIVE detection by analysis of trace amounts of tumour DNA in liquid biopsy specimens

Principal Investigators: Dr Robert Rintoul, Papworth Hospital & Dr Nitzan Rosenfeld, CRUK Cambridge Institute

Funded by: CRUK Early Detection Programme Award

Risk adaptive breast cancer screening: a tailored imaging approach

Principal Investigator: Professor Fiona Gilbert, School of Clinical Medicine and Addenbrooke’s Hospital, Cambridge
Joint Lead Applicant: Professor Paul Pharoah, Department of Public Health and Primary Care

Funded by: CRUK Early Detection Programme Award

Earlier Diagnosis in women at high risk of breast and ovarian cancer

Principal Investigator: Professor Doug Easton, Centre for Cancer Genetic Epidemiology,
Joint Lead Applicant: Dr Nitzan Rosenfeld, CRUK Cambridge Institute

Funded by: CRUK Early Detection Programme Award

Early detection of clinically-relevant mutational signatures

Principal Investigator: Dr Serena Nik-Zainal, MRC Cancer Unit

Funded by: CRUK Early Detection Project Award

PAN Cancer trial

Chief Investigator: Professor Rebecca Fitzgerald, MRC Cancer Unit
Principal Investigators:
Dr Massimiliano di Pietro, gastric and oesophageal cancers
Miss Alexandra Colquhoun, bladder cancer
Mr Vincent Gnanapragasam, prostate cancer
Mr Grant Stewart, renal cancer
Dr Edmund Godfrey, pancreatic cancer

Funded by: Owlstone Medical Ltd (sponsors) and CRUK Cambridge Centre

Evaluation of photoacoustic imaging data to delineate benign and malignant disease in breast cancer

Principal Investigator: Professor Fiona Gilbert, Department of Radiology
Co- Investigator: Dr Sarah Bohndiek, Department of Physics

Funded by: Cancer Research UK Cancer Imaging Centre in Cambridge and Manchester

The PRIM multi-centre study to refine and target early detection in prostate cancer using imaging and biomarkers

Principal Investigator: Vincent Gnanapragasam, Department of Surgery

Funded by: Addenbrooke's Charitable Trust & CRUK Cambridge Centre Urological Malignancies Programme

Feasibility of multi-spectral endoscopic imaging for detection of early neoplasia in Barrett's Oesophagus

Principal Investigator: Dr Sarah Bohndiek, Department of Physics
Co-Investigator: Professor Rebecca Fitzgerald, MRC Cancer Unit & Professor Tim Wilkinson, Department of Engineering

Funded by: Cancer Research UK and Stand Up to Cancer

Combination of confocal laser endomicroscopy and a molecular biomarker panel for the early diagnosis of neoplasia in Barrett's oesophagus

Principal Investigator: Dr Massimiliano di Pietro, MRC Cancer Unit
Co-Investigator: Professor Lorenz Wernisch, MRC Biostatistics Unit

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Developing a national framework to identify and monitor individuals with inherited cancer syndromes

Principal Investigator: Dr Marc Tischkowitz, Department of Medical Genetics
Co-Investigator: Professor Paul Pharoah, Department of Public Health and Primary Care

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Second primary tumour early detection (SPoTtED)

Principal Investigator: Dr Robert Rintoul, Papworth Hospital
Co-Investigator: Dr Yoryos Lyratzopoulos, Department of Public Health and Primary Care

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016