Clinical translation (evaluating new diagnostics and interventions)

ELUSIVE: Early-stage LUng and Second primary cancer non-invasIVE detection by analysis of trace amounts of tumour DNA in liquid biopsy specimens

Principal Investigators: Dr Robert Rintoul, Papworth Hospital & Dr Nitzan Rosenfeld, CRUK Cambridge Institute

Funded by: CRUK Early Detection Programme Award

Risk adaptive breast cancer screening: a tailored imaging approach

Principal Investigator: Professor Fiona Gilbert, School of Clinical Medicine and Addenbrooke’s Hospital, Cambridge
Joint Lead Applicant: Professor Paul Pharoah, Department of Public Health and Primary Care

Funded by: CRUK Early Detection Programme Award

Earlier Diagnosis in women at high risk of breast and ovarian cancer

Principal Investigator: Professor Doug Easton, Centre for Cancer Genetic Epidemiology,
Joint Lead Applicant: Dr Nitzan Rosenfeld, CRUK Cambridge Institute

Funded by: CRUK Early Detection Programme Award

Early detection of clinically-relevant mutational signatures

Principal Investigator: Dr Serena Nik-Zainal, MRC Cancer Unit

Funded by: CRUK Early Detection Project Award

PAN Cancer trial

Chief Investigator: Professor Rebecca Fitzgerald, MRC Cancer Unit
Principal Investigators:
Dr Massimiliano di Pietro, gastric and oesophageal cancers
Miss Alexandra Colquhoun, bladder cancer
Mr Vincent Gnanapragasam, prostate cancer
Mr Grant Stewart, renal cancer
Dr Edmund Godfrey, pancreatic cancer
Miss Victoria Snowdon, liver cancer

Funded by: Owlstone Medical Ltd (sponsors) and CRUK Cambridge Centre

Evaluation of photoacoustic imaging data to delineate benign and malignant disease in breast cancer

Principal Investigator: Professor Fiona Gilbert, Department of Radiology
Co- Investigator: Dr Sarah Bohndiek, Department of Physics

Funded by: Cancer Research UK Cancer Imaging Centre in Cambridge and Manchester

The PRIM multi-centre study to refine and target early detection in prostate cancer using imaging and biomarkers

Principal Investigator: Vincent Gnanapragasam, Department of Surgery

Funded by: Addenbrooke's Charitable Trust & CRUK Cambridge Centre Urological Malignancies Programme

Feasibility of multi-spectral endoscopic imaging for detection of early neoplasia in Barrett's Oesophagus

Principal Investigator: Dr Sarah Bohndiek, Department of Physics
Co-Investigator: Professor Rebecca Fitzgerald, MRC Cancer Unit & Professor Tim Wilkinson, Department of Engineering

Funded by: Cancer Research UK and Stand Up to Cancer

Combination of confocal laser endomicroscopy and a molecular biomarker panel for the early diagnosis of neoplasia in Barrett's oesophagus

Principal Investigator: Dr Massimiliano di Pietro, MRC Cancer Unit
Co-Investigator: Professor Lorenz Wernisch, MRC Biostatistics Unit

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Developing a national framework to identify and monitor individuals with inherited cancer syndromes

Principal Investigator: Dr Marc Tischkowitz, Department of Medical Genetics
Co-Investigator: Professor Paul Pharoah, Department of Public Health and Primary Care

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Second primary tumour early detection (SPoTtED)

Principal Investigator: Dr Robert Rintoul, Papworth Hospital
Co-Investigator: Dr Yoryos Lyratzopoulos, Department of Public Health and Primary Care

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016