New detection technologies

Genomic signatures in cell-free DNA and their role in early detection of cancer

Principal Investigators: Dr Nitzan Rosenfeld, University of Cambridge

Funded by: CRUK Early Detection Primer Award 2021

Establishing optimal methods for cancer early detection using methylation markers (EPITOME): An integrated comparison of three leading-edge platforms for cell-free DNA epigenetic analysis and application to multiple cancer types

Principal Investigators: Dr Charlie Massie, University of Cambridge; Dr Andrew Feber, University College London; Dr Olivier Gevaert, Stanford University; Dr Parag Mallick, Stanford University; Dr Chunxiao Song, University of Oxford (Affiliate)

Funded by: ACED Project Award 2020

Dynamic predictive model for baseline early detection and follow-up re-evaluation of the risk of prostate cancer progression on active surveillance (PROGRESS Prostate)

Principal Investigators: Prof Alexey Zaikin, University College London and Dr Tristan Barrett, University of Cambridge

Funded by: ACED Pilot Award 2020

Stratifying risk for early detection in hereditary breast and ovarian cancer

Principal Investigators: Dr Marc Tischkowitz, University of Cambridge; Dr Allison Kurian, Stanford University and Prof Gareth Evans, University of Manchester

Funded by: ACED Project Award 2020

Real-world risk-stratified early detection and diagnosis using linked electronic health records data

Principal Investigators: Prof Georgios Lyratzopoulos, University College London; Prof Antonis Antoniou, University of Cambridge and Prof Ruth Etzioni, Oregon Health and Science University

Funded by: ACED Project Award 2020

Novel tools for molecular imaging of pancreatic pre-neoplasia

Principal Investigators: Prof Kevin M Brindle, University of Cambridge and Prof H Tom Soh, Stanford University

Funded by: ACED Pilot Award 2020

Multi-parametric investigation and stratification of indeterminate lung nodules MISIL1

Principal Investigators: Dr Frank McCaughan, University of Cambridge and Dr Phil Crosbie, University of Manchester

Funded by: ACED Pilot Award 2020

Leverage protease activity in circulating hybrid cells and exosomes for early detection of cancer

Principal Investigators: Dr Jared Fischer, Oregon Health & Science University, Dr Utkan Demirci, Stanford University, Dr Melissa Wong, Oregon Health & Science University, Prof Antonis Antoniou, University of Cambridge

Funded by: ACED Pilot Award 2020

Tiered integrated diagnostics for the early detection of aggressive prostate cancer: The Riskman-TARGET study to develop a novel screening approach for prostate cancer.

Principal Investigators: Mr Vincent Gnanapragasam, University of Cambridge, Prof Kenneth Muir, University of Manchester, Dr Artitaya Lophatananon, University of Manchester

Funded by: ACED Pilot Award 2020

Early Detection of hereditary renal cancer (RCC) [ELECTRIC]

Principal Investigators: Dr Emma Woodward, University of Manchester, Dr Alice Fan, Stanford University and Prof Eamonn Maher, University of Cambridge

Funded by: ACED Pilot Award 2020

Organic Opto-Acoustic electronics for early stage detection of cancer

Principal Investigator: Dr Bruno Matarese, Department of Physics

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2020

Sampling of fallopian tube cells for functional and genotypic characterisation

Principal Investigator: Dr Filipe Correia Martins, Department of Obstetrics & Gynaecology

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2020

Epigenetic enrichment of circulating tumour DNA to enable deep profiling for cancer early detection (EpiEnrich)

Principal Investigator: Team EpiEnrich led by Dr Charlie Massie, CRUK Cambridge Centre Early Detection Programme

Funded by: Cancer Research UK Early Detection Innovation Award (through sensor technology for liquid biopsy sandpit)

Poly-dopamine based nano-senolytics for specific removal of senescent cells

Principal Investigator: Dr Ljiljana Fruk, Department of Chemical Engineering and Biotechnology

Funded by: Cancer Research UK Early Detection Primer Award

Early detection of renal cell carcinoma using DNA methylation markers in urine

Principal Investigators: Dr Charlie Massie & Assistant Professor Oliver Gevaert

Funded by: Cancer Research UK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

A multi-modal approach to discover novel blood based biomarkers for early detection of poor prognosis prostate cancer

Principal Investigators: Mr Vincent Gnanapragasam & Assistant Professor Tanya Stoyanova

Funded by: Cancer Research UK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

Hyperspectral Endoscopy Imaging for Early Detection of Precancerous Lesions in Average Risk and Inflammatory Bowel Disease Patients: Proof of Principle

Principal Investigators: Dr Sarah Bohndiek, (Cambridge), Dr Liana Tsikitis & Sarah Diamond (OHSU)

Funded by: OHSU-CRUK SPARK Award 2018

Early cancer detection through transcriptomic analysis of host immune cells

Principal Investigators: Dr Robert Rintoul & Professor Tom Soh

Funded by: Cancer Research UK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

Levitating a sponge for the early detection of oesophageal adenocarcinoma

Principal Investigators: Professor Rebecca Fitzgerald & Professor Utkan Demirci

Funded by: Cancer Research UK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

Analysing menstrual fluid at the single cell lever and assaying its suitability for the derivation of epithelial organoids

Principal Investigator: Dr Angela Goncalves, Wellcome Trust Sanger Institute
Co-Investigator: Dr Daniel Gaffney, Cambridge Cardiovascular

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Gynaecological Cancers Pump Priming Award 2017

Point-of-care measurement of PSA subtypes using acoustic sensors for early detection of aggressive prostate cancer

Principal Investigator: Dr Andrew Flewitt, Department of Electrical Engineering
Co-investigator: Mr Vincent Gnanapragasam, Department of Surgery

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Investigation into the accumulation of amyloid as a biomarker for cancer

Principal Investigator: Dr Susana Ros, CRUK Cambridge Institute
Co-Investigator: Professor David Klenerman, Department of Physical Chemistry

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Using holographic capsule technology to develop a test for oesophageal cancer

Principal Investigator: Dr George Gordon, Department of Engineering
Co-Investigator: Professor Tim Wilkinson, Department of Engineering

Funded by: Cancer Research UK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Design, synthesis and in vitro validation of novel tools for lung cancer diagnosis

Principal Investigator: Dr Daniel Muñoz-Espín, CRUK Cambridge Centre Early Detection Programme

Funded by: Medical Research Council (MRC)