New detection technologies

Epigenetic enrichment of circulating tumour DNA to enable deep profiling for cancer early detection (EpiEnrich)

Principal Investigator: Team EpiEnrich led by Dr Charlie Massie, CRUK Cambridge Centre Early Detection Programme

Funded by: CRUK Early Detection Innovation Award (through sensor technology for liquid biopsy sandpit)

Poly-dopamine based nano-senolytics for specific removal of senescent cells

Principal Investigator: Dr Ljiljana Fruk, Department of Chemical Engineering and Biotechnology

Funded by: CRUK Early Detection Primer Award

Early detection of renal cell carcinoma using DNA methylation markers in urine

Principal Investigators: Dr Charlie Massie & Assistant Professor Oliver Gevaert

Funded by: CRUK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

A multi-modal approach to discover novel blood based biomarkers for early detection of poor prognosis prostate cancer

Principal Investigators: Mr Vincent Gnanapragasam & Assistant Professor Tanya Stoyanova

Funded by: CRUK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

Hyperspectral Endoscopy Imaging for Early Detection of Precancerous Lesions in Average Risk and Inflammatory Bowel Disease Patients: Proof of Principle

Principal Investigators: Dr Sarah Bohndiek, (Cambridge), Dr Liana Tsikitis & Sarah Diamond (OHSU)

Funded by: OHSU-CRUK SPARK Award 2018

Early cancer detection through transcriptomic analysis of host immune cells

Principal Investigators: Dr Robert Rintoul & Professor Tom Soh

Funded by: CRUK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

Levitating a sponge for the early detection of oesophageal adenocarcinoma

Principal Investigators: Professor Rebecca Fitzgerald & Professor Utkan Demirci

Funded by: CRUK Cambridge Centre and Canary Center at Stanford Early Detection Joint Pump Priming Awards 2018

Analysing menstrual fluid at the single cell lever and assaying its suitability for the derivation of epithelial organoids

Principal Investigator: Dr Angela Goncalves, Wellcome Trust Sanger Institute
Co-Investigator: Dr Daniel Gaffney, Cambridge Cardiovascular

Funded by: CRUK Cambridge Centre Early Detection Programme Gynaecological Cancers Pump Priming Award 2017

Point-of-care measurement of PSA subtypes using acoustic sensors for early detection of aggressive prostate cancer

Principal Investigator: Dr Andrew Flewitt, Department of Electrical Engineering
Co-investigator: Mr Vincent Gnanapragasam, Department of Surgery

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Investigation into the accumulation of amyloid as a biomarker for cancer

Principal Investigator: Dr Susana Ros, CRUK Cambridge Institute
Co-Investigator: Professor David Klenerman, Department of Physical Chemistry

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Using holographic capsule technology to develop a test for oesophageal cancer

Principal Investigator: Dr George Gordon, Department of Engineering
Co-Investigator: Dr Sarah Bohndiek, Department of Physics

Funded by: CRUK Cambridge Centre Early Detection Programme Pump Priming Awards 2016

Design, synthesis and in vitro validation of novel tools for lung cancer diagnosis

Principal Investigator: Dr Daniel Muñoz-Espín, CRUK Cambridge Centre Early Detection Programme

Funded by: Medical Research Council (MRC)