Earlier Diagnosis in women at high risk of breast and ovarian cancer

Principal Investigators: Professor Doug Easton & Dr Nitzan Rosenfeld

Funded by: CRUK Early Detection Programme Award

The team, led by Doug Easton, Professor of Genetic Epidemiology, and Nitzan Rosenfeld, Group Leader, CRUK Cambridge Institute, will establish a cohort of women at high risk of breast and ovarian cancer to investigate the potential to use DNA in blood or cervical samples for the early detection of the two cancers using state-of-the-art methodology. The research will establish whether current methods of ctDNA analysis, using either blood or cervical samples, are sufficiently sensitive to have utility in early detection and will determine the relative sensitivity in different risk groups. It is hoped that the results will inform the design of future trials to establish the utility of such methods in clinical practice.