Jamie Blundell’s lab works on understanding how mutant clones arise, expand and compete in our tissues as we age. Focusing predominantly on blood, we use novel genetic lineage tracking tools and deep sequencing of longitudinal samples to identify mutant clones which are under strong positive selection. Such clones are implicated in early cancer and thus are candidates for improved cancer detection.
Using genetic and epigenetic alterations found in early prostate cancer Charlie Massie's uro-oncology early detection lab will create assays for sensitive detection and quantification of cell-free tumour DNA and develop molecular prognostic scores to help stratify early stage prostate tumours. More accurate risk stratification will spare men with indolent disease from the risks of unnecessary over treatment, and allow more targeted interventions in men with high-risk disease. Click here for the latest updates on ctDNA and liquid biopsy.