The results of a pilot first-in-human clinical trial demonstrate that using a spectral endoscopy, rather than conventional white-light, gives a more detailed, high-contrast image, helping to differentiate between healthy and cancerous cells more easily.
Dale Waterhouse led the study while he was a research associate in the Bohndiek Vision Lab. The aim of the research was to show that spectral endoscopy could enhance contrast for neoplasia in surveillance of patients with Barrett's oesophagus.
A custom spectral endoscope was used in a study of 20 patients to capture 715 in vivo tissue spectra matched with gold standard diagnosis from histopathology.
The study suggests that multispectral cameras gave ten times or more the contrast from using normal optical ones. This imaging technique could also have many other applications for detecting and treating cancer.
Dale is continuing his research in spectral imaging techniques as a Research Fellow in the Surgical Robot Vision group at the Wellcome/EPSRC Centre for Interventional and Surgical Sciences.
The paper was published in the May 2021 issue of Cancer Research:
Cancer Res May 26 2021 DOI: 10.1158/0008-5472.CAN-21-0474