Our sincerest congratulations go to Dr David Macias Gutierrez in Daniel Muñoz-Espín's lab who has just been announced as the recipient of a competitive Marie Skłodowska-Curie individual fellowship. The prestigious programme allows researchers to work on projects in their chosen research field while receiving training and supervision to enhance their skills and boost their careers.
David focussed his previous work on how organisms respond and adapt to oxygen availability with emphasis on cardiorespiratory responses controlled by the carotid body (a specialised organ that senses oxygen levels in arterial blood and controls respiratory and cardiovascular function accordingly). In particular, he was interested in how the hypoxia signalling pathway regulates the development and function of the carotid body and its impact on highly prevalent medical conditions such as pulmonary arterial hypertension. Since 2018, he has been working as a postdoctoral researcher in the Muñoz-Espín lab to investigate molecular pathways involved in the maintenance and/or elimination of senescent cells in lung cancer.
In his Marie Curie proposal, he plans to combine his expertise on hypoxia signalling with his current interest in cellular senescence. He will study the role of hypoxia in regulating the intensity and composition of the senescence associated secretory phenotype (SASP) in its impact on age-related pathologies such as cancer and neurodegenerative disorders.
The award will see David returning to the Institute of Biomedicine of Seville (IBiS-University of Seville), where he undertook his first postdoctoral post.
David commented: “I am still in shock with the good news! I am pleased to be awarded such a competitive Fellowship. It is a great opportunity for me to return to my home country and, eventually, to start my own research group. Given the competitive nature of this call, some Spanish Universities are offering a permanent position at the lecturer or senior lecturer level to Marie Curie Fellows after its conclusion. I hope to keep a collaboration with Daniel and the ED programme for the cancer arm of the project.”