Cambridge researchers behind new findings which could change the way we think about DCIS in the clinic

Congratulations to Serena Nik Zainal and Helen Davies on their latest paper, out now in Nature Genetics.

Ductal carcinoma in situ (DCIS), a non-invasive breast lesion, has long been assumed to be the precursor of any invasive breast cancer that follows. But this new research shows that 1 in 5 of these subsequent cancers are unrelated to the initial lesion - and instead are new primary tumours. These paradigm-shifting findings could change the way people with DCIS are treated in the clinic.

Serena and Helen are part of a global team of researchers funded through Cancer Grand Challenges, taking on a challenge to distinguish between people with DCIS who urgently need therapy and people who could safely avoid treatment. Their work could collectively save thousands of people the burden of treatment with little benefit to them.

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