Forthcoming Events

UCL ACED Lecture Series: Using evolutionary principles to predict who is most at risk of developing leukaemia

Date: Friday 28th February 2020
Time: 13:00 - 14:00
Venue: B17 Basement Lecture Theatre, 1-19 Torrington Place, UCL

Using evolutionary principles to predict who is most at risk of developing leukaemia is a talk by Dr Blundell. Dr Blundell is a UKRI Future Leaders Fellow and group leader in the CRUK Cambridge Centre Early Detection Programme. He trained as a theoretical physicist at Cambridge and then as a quantitative biologist at Stanford. In 2017 he established his own group in the early detection programme in Cambridge. His lab studies the somatic evolution that occurs in healthy tissues as we age and how this evolution is altered at the earliest stages of cancer. Focusing on dynamic changes in blood, Jamie’s lab develops and applies novel ultra-sensitive sequencing technologies to large collections of longitudinal blood samples and then applies quantitative principles from evolutionary theory to develop personalised “forecasts” of future cancer risk and identify those most in need of intervention. The lab is also interested in adaptive immune repertoire dynamics in cancer and other disease.

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Early Detection Special Seminar: Cellular and molecular characterisation of epithelial tumour initiation

Date: Friday 6th March 2020
Time: 10:00 - 11:00
Venue: Sackler Lecture Theatre, Cambridge Institute for Medical Research (level 7), Cambridge Biomedical Campus

Dr Walid Khaled is currently a University Lecturer in the Department of Pharmacology at the University of Cambridge and will give a special seminar for the Early Detection Programme. We encourage you to attend.

Talk Abstract:

Dr Khaled's research focus is driven by the fact that we still have little understanding of how hundreds of identified genetic aberrations impact tissue homeostasis leading to tumour development. While hugely significant, work to date on large-scale sequencing efforts and a handful of well-characterised mutations has barely scratched the surface and the early stages of precancer tumour development remains poorly understood. Yet, it has a huge potential to improve success rates of early detection, prevention and treatment of cancer. Recent sequencing studies of normal tissue suggest that acquiring putative oncogenic drivers is not sufficient to initiate tumour development. This points towards elements, such as the cell of origin, differentiation state and the microenvironment, all playing a key role in mediating tumour initiation. In this talk Walid Khaled will discuss the works my laboratory has been doing on defining the early cellular and molecular events that drive tumour initiation and development. In particular, we focus on how the cell of origin affects the differentiation trajectory of nascent tumour cells and dictates changes in the microenvironment thus enabling tumour growth and immune evasion. I will show how such studies can be used to for the development of new approaches for the early detection of tumour initiation.

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Cambridge Science Festival Event: Harnessing big clinical data in medicine - can AI improve Breast Cancer Screening?

Date: Monday 9th March 2020
Time: 18:00-20:00
Venue: Barbara White Room, Newnham College, Cambridge CB3 9DF

2.2 million women are screened for breast cancer each year in the UK. Can AI identify women at most risk of cancer, improve the performance of the radiologists reading the mammograms or even replace the readers?

Book your place here

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Breakfast meeting: CT screening for lung cancer is coming – but can biomarkers help enrich the populations to screen?

Date: Thursday 12th March 2020
Time: 08:30 - 09:30
Venue: Jeffrey Cheah Restaurant, Puddicombe Way, Cambridge, CB2 0AF

These meetings are an opportunity for researchers across Cambridge and further afield who are engaged with our programme to network with fellow researchers in an informal setting. This breakfast meeting is a a joint meeting with the CRUK Cambridge Centre Aerodigestive Programme.

Dr Robert Rintoul, Reader in Thoracic Oncology in the Department of Oncology, University of Cambridge and Honorary Respiratory Physician, Royal Papworth Hospital, will open this breakfast meeting on "CT screening for lung cancer is coming – but can biomarkers help enrich the populations to screen?".

Early Detection Special Seminar: Quantitative approaches towards understanding multicellular organisation and communication

Date: Friday 13th March 2020
Time: 10:00-11:00
Venue: Sackler Lecture Theatre, Cambridge Institute for Medical Research (level 7), Cambridge Biomedical Campus

Dr Heba Sailem, Sir Henry Wellcome Fellow at the Institute of Biomedical Engineering and Big Data Institute, will give a special seminar for the Early Detection Programme. We encourage you to attend.

Talk Abstract:

Multicellular organisation requires the coordination of multiple signalling pathways that regulate cell shape as well as cell-cell and cell-micro environment interactions. Such coordination is often lost in cancer resulting in changes in tissue architecture, uncontrolled growth, and metastasis. Imaging technologies provide a powerful approach to simultaneously study the signalling and organisational state of cells. I will discuss the development of machine learning and computer vision methodologies for automated identification of genetic programmes underlying tissue organisation. Importantly, these studies reveal that cell context and shape can modulate cell signalling even in isogenic cell cultures. Using orthogonal datasets and integrative approaches, we validate the clinical relevance of cell shape and context in patient prognosis.

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Cambridge Science Festival Event: Cancer - the importance of early detection

Date: Sunday 22nd March 2020
Time: 11:00-16:00
Venue: Cambridge Academy for Science and Technology, Robinson Way (close to junction of Robinson Way and Long Road), CB2 0SZ

Researchers from the MRC Cancer Unit and the Hutchison MRC Research Centre will demonstrate the vitally imprtant and diverse research that they are doing to address key questions about how to tackle Cancer at its earliest stages - be it through early detection, patient stratification or through novel early intervention.

We will be there with lots of hands on activities for all ages to tell you more about what we do and how we are trying to combat cancer early.

No registration required.

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Breakfast meeting: on The Cambridge Biorepository for Translational Medicine, immuno-oncology and early cancer detection​

Date: Thursday 14th May 2020
Time: 08:30 - 09:30
Venue: Jeffrey Cheah Restaurant, Puddicombe Way, Cambridge, CB2 0AF

These meetings are an opportunity for researchers across Cambridge and further afield who are engaged with our programme to network with fellow researchers in an informal setting.

Mr Kourosh Saeb-Parsy, University Lecturer and Honorary Consultant Transplant Surgeon, will open this breakfast meeting on "The Cambridge Biorepository for Translational Medicine, immuno-oncology and early cancer detection".

2nd International DKFZ Conference on Cancer Prevention: Facing the Challenges of Cancer Prevention and Early Detection

Date: 17th-18th September 2020
Venue: German Cancer Research Center (DKFZ), Communication Center Lecture Hall, Heidelberg, Germany

Abstract submission for the 2nd International DKFZ Conference on Cancer Prevention will open on 2nd March, deadline 27th April. Registration deadline 6th July 2020


The Early Detection of Cancer Conference

Date: 6th-8th October 2020
Venue: Central Hall Westminster, Storey's Gate, London SW1H 9NH

Cancer Research UK, OHSU Knight Cancer Institute and the Canary Center at Stanford, present the Early Detection of Cancer Conference series. This annual Conference brings together experts in early detection from multiple disciplines to share ground breaking research and progress in the field.

The Conference is part of a long-term commitment to invest in early detection research, to understand the biology behind early stage cancers, find new detection and screening methods, and enhance uptake and accuracy of screening.

Further information and registration